 | Dolph Lundgren als He-Man |
 | Frank Langella als Skeletor |
 | Meg Foster als Evil-Lyn |
 | Billy Barty als Gwildor |
 | Courteney Cox als Julie Winston |
 | Robert Duncan McNeill als Kevin Corrigan |
 | Jon Cypher als Man At Arms |
 | Chelsea Field als Teela |
 | James Tolkan als Detective Lubic |
 | Christina Pickles als Sorceress |
 | Tony Carroll als Beast Man |
 | Pons Maar als Saurod |
 | Anthony De Longis als Blade |
 | Robert Towers als Karg |
 | Barry Livingston als Charlie |
| Jessica Nelson als Monica |
 | Gwynne Gilford als Mrs. Winston |
 | Walter Scott als Mr. Winston |
 | Walter Robles als Carl the Janitor |
| Cindi Eyman als Gloria |
| Peter Brooks als Narrator (voice) |
 | Richard Szponder als Pigboy |
 | Mike Carlucci als Warlord (uncredited) |
| Nicholas Grabowsky als Skeletor's Dark Trooper |
| Anne V. Coates | Editor |
| Menahem Golan | Producer |
| Gary Goddard | Director |
| Edward R. Pressman | Executive Producer |
| Yoram Globus | Producer |
| David Odell | Screenplay |
| Hanania Baer | Director of Photography |
| Bill Conti | Original Music Composer |
| Robert Howland | Art Direction |
| Joe Griffith | Conceptual Design |
| Julie Weiss | Costume Design |
| Lynn Christopher | Assistant Art Director |
| Claudio Mazzoli | Conceptual Design |
| Victoria Thomas | Casting |
| Wenden K. Baldwin | Title Designer |
| William Stout | Production Design |
| Mike Johnson | Set Decoration |
| Kathe Klopp | Set Decoration |
| Edward Eyth | Conceptual Design |
| Mary K. Perko | Art Department Coordinator |
| Lawrence Richter | Wardrobe Supervisor |
| Daniel Gluck | Set Decoration |
| Ken Sax | Still Photographer |
| Adrienne Hamalian-Mangine | Script Supervisor |
| Robert R. Rutledge | Supervising Sound Editor |
| Helen Hahn | Negative Cutter |
| Deborah Gaydos | Animation |
| Mark Goodermote | Boom Operator |
| Zandra Platzek | Hairstylist |
| Stephen A. Hope | Music Editor |
| Jenny Weyman-Cockle | ADR Editor |
| Mary Jo Devenney | Boom Operator |
| Gary C. Bourgeois | Sound Re-Recording Mixer |
| Michael E. Little | First Assistant Camera |
| Paula Erickson | Music Supervisor |
| Mauro Maressa | Animation |
| George Berndt | ADR Supervisor |
| Dean Okrand | Sound Re-Recording Mixer |
| John A. Larsen | Supervising Sound Editor |
| Dan Elsasser | Camera Operator |
| Glenn Chaika | Animation |
| Michael Van Himbergen | Visual Effects Coordinator |
| Dennis Michelson | Visual Effects Editor |
| Robert Martel | Foley Editor |
| James Rosenthal | Gaffer |
| Paulette Smook Marshall | Special Effects Supervisor |
| Anna Behlmer | Sound Recordist |
| Ed Novick | Sound Designer |
| Robin Beauchesne | Makeup Artist |
| Brent Boates | Visual Effects Art Director |
| Terry Windell | Visual Effects Art Director |
| Rexford L. Metz | VFX Director of Photography |
| Kyle Seidenbaum | Title Designer |
| Eusebio Torres | Animation |
| Michael Backauskas | Visual Effects Editor |
| Chris Carpenter | Sound Re-Recording Mixer |
| Lori Benson | Hairstylist |
| June Westmore | Makeup Artist |
| Skip Cook | Key Grip |
| Marilyn McCoppen | ADR Editor |
| Stanley B. Gill | Sound Recordist |
| Rick Davis | Dolly Grip |
| Ron McCausland | Rigging Grip |
| Bill Neil | VFX Director of Photography |
| Michael Westmore | Makeup Designer |
| Ellen Kitz | Special Effects Supervisor |
| Todd McIntosh | Makeup Department Head |
| Garry Waller | Visual Effects Supervisor |
| Angelo Di Biase | Hairstylist |
| Stephen Milburn Anderson | Location Manager |
| Bart Heimburger | Location Manager |
| Alan Gershenfeld | Production Manager |
| Alain Jakubowicz | Post Production Supervisor |
| Cynthia R. Woodard | Location Manager |
| Michael Flynn | Associate Producer |
| Elliot Schick | Co-Producer |
| Elliot Schick | Production Manager |
| Evzen Kolar | Associate Producer |
| Renee Milliken | Casting Assistant |
| Michael Alden | Post Production Supervisor |
| Lillian Glass | Dialogue Coach |
| Michael Reinhart | Construction Foreman |
| Frederic B. Blankfein | First Assistant Director |
| Walter Scott | Stunt Coordinator |
| Brian H. Reynolds | Key Grip |
| Christopher Cibelli | Assistant Editor |
| Leo Rijn | Sculptor |
| John Eyler | Second Assistant Director |
| Douglas E. Maxwell | Leadman |
| Anthony De Longis | Stunt Double |
| James D. McGeachy | Armorer |
| Richard Edlund | Visual Effects Supervisor |
| Douglas S. Turner | Armorer |
| Douglas S. Turner | Costume Coordinator |
| Loren Janes | Stunt Coordinator |
| Mark Buckalew | Best Boy Electric |
| Tony Brubaker | Stunts |
| Charles Croughwell | Stunts |
| Janet Brady | Stunts |
