 | Ewan McGregor als Rodney Copperbottom (voice) |
 | Robin Williams als Fender (voice) |
 | Halle Berry als Cappy (voice) |
 | Amanda Bynes als Piper (voice) |
 | Mel Brooks als Bigweld (voice) |
 | Jim Broadbent als Madame Gasket (voice) |
 | Greg Kinnear als Ratchet (voice) |
 | Stanley Tucci als Herb Copperbottom (voice) |
 | Dianne Wiest als Mrs. Copperbottom (voice) |
 | Drew Carey als Crank (voice) |
 | Harland Williams als Lug (voice) |
 | Jennifer Coolidge als Aunt Fanny (voice) |
 | Paul Giamatti als Tim the Gate Guard (voice) |
 | Natasha Lyonne als Loretta Geargrinder (voice) |
 | Chris Wedge als Wonderbot / Phone Booth (voice) |
 | Dan Hedaya als Mr. Gunk (voice) |
 | Marshall Efron als Lamppost / Toilet Bot / Bass Drum / Microphone |
 | Terry Bradshaw als Broken Arm Bot (voice) |
 | Al Roker als Mailbox (voice) |
 | Lucille Bliss als Pigeon Lady (voice) |
 | Jay Leno als Fire Hydrant (voice) |
 | Lowell Ganz als Mr. Gasket (voice) |
 | Paula Abdul als Watch (voice) |
 | Jackie Hoffman als Water Cooler (voice) |
 | Brian Scott McFadden als Trashcan Bot (voice) |
 | Tim Nordquist als Tin Man (voice) |
 | James Earl Jones als Voice Box at Hardware Store (voice) |
 | Damien Fahey als Stage Announcer (voice) |
 | Stephen Tobolowsky als Bigmouth Executive / Forge (voice) |
 | Jansen Panettiere als Younger Rodney (voice) |
 | Will Denton als Young Rodney (voice) |
 | Crawford Wilson als Young Rodney (voice) |
| Dylan Denton als Youngest Rodney (voice) |
| Jennifer Perito als Additional Voices |
 | Alan Rosenberg als Jack Hammer (voice) |
 | Lara Cody als Additional Voices |
| Cooper Cowgill als Additional Voices |
 | David Crommett als Additional Voices |
 | Darin De Paul als Additional Voices |
 | Dann Fink als Additional Voices |
| Timothy Gulan als Additional Voices |
 | Ray Iannicelli als Additional Voices |
 | Sondra James als Additional Voices |
 | Vanessa Lemonides als Additional Voices |
| Marcus Maurice als Additional Voices |
| David Rossmer als Additional Voices |
 | Bruce Winant als Additional Voices / ADR Loop Group |
 | Chris Moyles als Stage Announcer (voice) |
 | Chingy als DJ Robot (uncredited) |
| Sean Garnhart als Diesel (uncredited) |
| Paul Urmson als Diesel (uncredited) |
 | Randy Jackson als Watch #2 (voice) (uncredited) |
 | James Brown als Diesel (archive footage) (uncredited) |
| Chris Meledandri | Executive Producer |
| Christian Kaplan | Casting |
| John Powell | Original Music Composer |
| William Joyce | Production Design |
| Lorne Orleans | Producer |
| John C. Donkin | Producer |
| Chris Wedge | Director |
| Lowell Ganz | Screenplay |
| Jim McClain | Story |
| David Lindsay-Abaire | Story |
| William Joyce | Producer |
| Ron Mita | Story |
| David Lindsay-Abaire | Screenplay |
| John Carnochan | Editor |
| Babaloo Mandel | Screenplay |
| Bob Gordon | Co-Producer |
| Jerry Davis | Producer |
| Jeannine Berger | Post Production Supervisor |
| Arun Ram-Mohan | Lighting Artist |
| Sean Garnhart | Sound Designer |
| Michael J. Travers | CG Supervisor |
| Brett Hoffman | Script Coordinator |
| Jennifer Kagel | Production Coordinator |
| Anthony Nisi | Production Supervisor |
| Frank Bennett | Orchestrator |
| Doug Letterman | Software Engineer |
| Luke Martorelli | Master Lighting Artist |
| Jim Passon | Color Timer |
| Buck Lewis | Visual Development |
| Alex John Cuthbert | Systems Administrators & Support |
| Becky Mancuso-Winding | Music Supervisor |
| Kent Beyda | Additional Editing |
| Maria Criscuolo | Unit Production Manager |
| Jess Bressler | Lighting Technician |
| Wim Post | Sound Re-Recording Mixer |
| Mike Thurmeier | Supervising Animator |
| Andrea Blasich | Layout |
| Wyatt Sprague | Sound Effects Editor |
| James Palumbo | First Assistant Editor |
| Eric Putz | Telecine Colorist |
| Terry Ziegelman | Lighting Artist |
| David Esneault | Lighting Supervisor |
| Tim Gomillion | Sound Recordist |
| Paul Ohrt | Production Accountant |
| Thomas A. Carlson | Music Editor |
| Kent Beyda | Thanks |
| Bill Orrico | First Assistant Sound Editor |
| John A. Patterson | Visual Effects |
| Augusto Schillaci | Visual Effects Supervisor |
| Steve Martino | Art Direction |
| Brandon Oldenburg | Conceptual Design |
| Marissa Littlefield | Dialogue Editor |
| Nicholas Renbeck | Supervising ADR Editor |
| Nicholas Renbeck | Supervising Dialogue Editor |
| Robert Fernandez | Scoring Mixer |
| Moroni Taylor | Storyboard Artist |
| Jamie Williams | Visual Effects Technical Director |
| Jo Mion | ADR Editor |
| David Brown | In Memory Of |
| Mark Piretti | Rigging Supervisor |
| Neal Sternecky | Story Artist |
| Pete Anthony | Conductor |
| Curtis Lindersmith | Digital Intermediate Editor |
| Galen T. Chu | Lead Animator |
| Brian Morgan | Assistant Editor |
| Tim Nordquist | Associate Editor |
| Dorothy Joo | Music Coordinator |
| Allen Dam | Production Consultant |
| Christopher Kappler | Human Resources |
| David Lucarelli | ADR Recordist |
| Justin Mandel | Intern |
| Billy Foster | Assistant Production Manager |
| Melanie Martini | Production Assistant |
| Marko Costanzo | Foley Artist |
| Colette D. Dahanne | ADR Mixer |
| Mark Filip | Apprentice Sound Editor |
| Peter DeSève | Character Designer |
| Paul Urmson | Sound Effects Designer |
| Natasha Leonnet | Digital Color Timer |
| Derek Casari | ADR Engineer |
| Bob Camp | Storyboard Artist |
| Lorene Simpson | Digital Intermediate Producer |
| Matt Seckman | Digital Compositor |
| Gary Burritt | Negative Cutter |
| Johnny Gidcomb | ADR Voice Casting |
| Robert V. Cavaleri | Effects Supervisor |
| Carlos Saldanha | Co-Director |
| Paul Downs | Animation |
| David Tart | Animation |
| Enrico Casarosa | Storyboard Artist |
| Robert Cardone | Layout Supervisor |
