 | Tom Holland als Peter Parker / Spider-Man |
 | Michael Keaton als Adrian Toomes / Vulture |
 | Robert Downey Jr. als Tony Stark / Iron Man |
 | Marisa Tomei als May Parker |
 | Jon Favreau als Harold 'Happy' Hogan |
 | Gwyneth Paltrow als Virginia 'Pepper' Potts |
 | Zendaya als Michelle 'MJ' Jones |
 | Donald Glover als Aaron Davis |
 | Jacob Batalon als Ned |
 | Laura Harrier als Liz |
 | Tony Revolori als Eugene 'Flash' Thompson |
 | Bokeem Woodbine als Herman Schultz / Shocker |
 | Tyne Daly als Anne Marie Hoag |
 | Abraham Attah als Abraham |
 | Hannibal Buress als Coach Wilson |
 | Kenneth Choi als Principal Morita |
 | Selenis Leyva als Ms. Warren |
 | Angourie Rice als Betty Brant |
 | Martin Starr als Mr. Harrington |
 | Garcelle Beauvais als Doris Toomes |
 | Michael Chernus als Phineas Mason / Tinkerer |
 | Michael Mando als Mac Gargan |
 | Logan Marshall-Green als Jackson Brice / Shocker |
 | Jennifer Connelly als Karen (voice) |
 | Gary Weeks als Agent Foster |
 | Christopher Berry als Randy |
 | Jorge Lendeborg Jr. als Jason Ionello |
 | Tunde Adebimpe als Mr. Cobbwell |
 | Tiffany Espensen als Cindy |
 | Isabella Amara als Sally |
 | Michael Barbieri als Charles |
 | Josie Totah als Seymour |
 | Hemky Madera als Mr. Delmar |
 | Zach Cherry als Street Vendor |
 | Kirk R. Thatcher als Punk on Street |
 | Yu Lew als Car Jacker |
 | Sondra James als Yelling Woman |
 | Bob Adrian als Yelling Man |
 | Gary Richardson als Day Sleeper |
 | Stan Lee als Gary |
 | Joe Hang als Thai Waiter |
 | Wayne Pére als History Teacher |
 | Chris Evans als Steve Rogers / Captain America |
 | Alexa Laraki als Tent Kid |
 | Liza Fagin als Tent Kid |
 | Kerry Condon als F.R.I.D.A.Y. (voice) |
 | John Penick als Mr. Hapgood |
 | Ethan Dizon als Tiny |
 | Amy Hill als Decathlon Moderator |
 | Miles Mussenden als Park Ranger |
 | Martha Kelly als Tour Guide |
| Kevin LaRosa Jr. als Helicopter Pilot |
| Ren Colley als Ferry Kid |
 | Jennifer Kim als Ferry Mom |
 | Ari Groover als Ferry Commuter |
| Louis Gonzalez als Ferry Commuter |
 | Stewart Steinberg als Ferry Commuter |
 | Andy Powers als Ferry Commuter |
 | Omar Capra als Yeah Spider-Man Guy |
 | Nitin Nohria als Dean Crimson |
 | Vince Foster als Stark Tower Technician |
 | Brian Schaeffer als Stark Tower Employee |
 | Chris Adams als NYC Pedestrian (uncredited) |
 | Maiya Boyd als Indian Flower Girl (uncredited) |
 | Rebeca Donovan als Drama Club Member (uncredited) |
 | Elli als Rabbi on Subway (uncredited) |
 | Nickolas Wolf als Mascot (uncredited) |
 | Jaine Ye als Chemistry Student (uncredited) |
 | Gina Cordan als DC Tourist (uncredited) |
 | Friday Chamberlain als Skateboarder (uncredited) |
 | Dante Brattelli als Homecoming Dance Student (uncredited) |
 | Melissa Kay Glaze als New Yorker (uncredited) |
 | Donald K. Overstreet als Avenger's Staff Agent (uncredited) |
 | Hallie Ricardo als DC News Reporter (uncredited) |
 | Doug Scroggins III als Stark VTOL Pilot (uncredited) |
 | Marmee Regine Cosico als NY Pedestrian (uncredited) |
 | Harrison Osterfield als Midtown High Student |
 | Chris Silcox als Helicopter D.C. Metro Sniper (uncredited) |
| Kevin Feige | Producer |
| Amy Pascal | Producer |
| Stan Lee | Executive Producer |
| Sarah Halley Finn | Casting |
| Beat Frutiger | Art Direction |
| Lauren Abiouness | Art Direction |
| Gene Serdena | Set Decoration |
| Oliver Scholl | Production Design |
| Louise Frogley | Costume Design |
| Eric Hauserman Carroll | Co-Producer |
| Nadia Paine | Unit Production Manager |
| Joe Lemola | Sound Effects Editor |
| Rachel Block | Assistant Art Director |
| Kellie Robinson | Hairstylist |
| Chris Diebold | Sound Effects Editor |
| Debbie Berman | Editor |
| Luis Galdames | Sound Effects Editor |
| Bob Kellough | Sound Effects Editor |
| Felipe Borrero | Sound Mixer |
| Leeann Stonebreaker | Unit Production Manager |
| Lucy O'Reilly | Makeup Department Head |
| Lauri Gaffin | Set Decoration |
| Kat Percy | Hair Department Head |
| Jeri Baker | Hair Department Head |
| Jonathan Goldstein | Screenstory |
| Suzy Mazzarese-Allison | Key Hair Stylist |
| Drew Monahan | Art Direction |
| Don J. Hug | Production Supervisor |
| Ashley McGuire | Makeup Artist |
| Suzanna Boykin | Hairstylist |
| Seidah Nichols | Makeup Artist |
| Enrique Vega | Hairstylist |
| John Francis Daley | Screenstory |
| Dan Lebental | Editor |
| Jack Lazzaro | Makeup Artist |
| Joseph Negrete | Hairstylist |
| Denise Pugh-Ruiz | Makeup Artist |
| Janine Rath-Thompson | Hair Department Head |
| Brad Ricker | Supervising Art Director |
| Greg Funk | Key Makeup Artist |
| Kellie Robinson | Makeup Artist |
| Heba Thorisdottir | Makeup Department Head |
| Audra Avery | Art Direction |
| Michelle Diamantides | Hairstylist |
| Jillian Erickson | Makeup Department Head |
| Cynthia L. Chapman | Hair Department Head |
| Robert Wilson | Key Hair Stylist |
| Kyle David Crosby | Production Supervisor |
| Matt Tolmach | Executive Producer |
| Garet Reilly | Key Costumer |
| Berrian 'Scarecrow' Hobby IV | Rigging Grip |
| Chuck Zlotnick | Still Photographer |
| Rodney Fuentebella | Conceptual Illustrator |
| Justin Trudeau | Set Designer |
| Raul J. Marin | Rigging Grip |
| Heather Elwell | Art Department Coordinator |
| John Hoskins | Construction Coordinator |
| Salvatore Totino | Director of Photography |
| Deb Downing | Costume Coordinator |
| Bela Trutz | Steadicam Operator |
| Kevin Jackson | Rigging Grip |
| Lawrence Tarzy | Set Costumer |
| Peter Gulla | Camera Operator |
| Kirk Corwin | Property Master |
| Jared Slater | Aerial Camera |
| Dan Cornwall | Gaffer |
| Julia Gombert | Ager/Dyer |
| Carlane Passman | Costume Supervisor |
| Bruce MacCallum | Camera Operator |
| John D. Miller | Key Grip |
| Rick Marroquin | Key Grip |
| Cameron Beasley | Set Designer |
| Steve Constancio | Key Costumer |
| Jaimie Trueblood | Still Photographer |
| Henrik Tamm | Conceptual Illustrator |
| Ian Churchill | Ager/Dyer |
| Brad Shield | Second Unit Director of Photography |
| Lisa Halperin | Key Costumer |
| Yu Kil-won | Set Designer |
| Adam Harrison | Rigging Gaffer |
| Pyare Fortunato | Steadicam Operator |
| Bianca Siu Davies | Art Department Coordinator |
| Al Cerullo | Pilot |
| Branden Marks | Key Costumer |
| Jason B. Stamey | Casting Associate |
| Jason Velez | Gaffer |
| Ed Natividad | Conceptual Design |
| Dean Wolcott | Set Designer |
| Christian Cordella | Costume Illustrator |
| Brian Heller | Aerial Director of Photography |
| Will Arnot | Steadicam Operator |
| Gary Blair | Rigging Grip |
| Peter Zuccarini | Underwater Director of Photography |
| Jeffrey D. Simon | Assistant Art Director |
| Kerry Lyn McKissick | Script Supervisor |
| David Butler | Key Costumer |
| Susan J. Wright | Costume Supervisor |
| Bob Moore Jr. | Set Costumer |
| Joseph Kendrick | Rigging Grip |
| Tom Cummins | Key Set Costumer |
| Pimentel A. Raphael | Animation Supervisor |
| Valerie Bernard | Software Engineer |
| Maricel Pagulayan | Visual Effects Producer |
| Megan Flood | Visual Effects Supervisor |
| Viktor Lundqvist | Visual Effects Technical Director |
| Lisa Wang | Lead Animator |
| Elaine C. Andrianos | Visual Effects Editor |
| Marie Rheinschild-Jordan | Visual Effects Producer |
| Immanuel Morris | Visual Effects Supervisor |
| Dominik Zimmerle | Visual Effects Supervisor |
| Liz Bernard | Lead Animator |
| Doug Spilatro | Visual Effects Supervisor |
| Dawn Michelle King | First Assistant Editor |
| Alexandre Cancado | CG Supervisor |
| Joosten Kuypers | CG Supervisor |
| Jan Reichmann | VFX Editor |
| Kilou Picard | Visual Effects Producer |
| Scott Seungpil Jung | Visual Effects Technical Director |
| Elizabeth Hitt | Digital Intermediate |
| Chris Smallfield | CG Supervisor |
| Roy Malhi | CG Supervisor |
| Mike F. Hedayati | Visual Effects Supervisor |
| Arda Uysal | Lead Animator |
| Mariatta Wijaya | Software Engineer |
| John Clinton | Visual Effects Producer |
| Janek Sirrs | Visual Effects Supervisor |
| Barry Goch | Digital Intermediate |
| Richard Smith | Animation Supervisor |
| Taisuke Tanimura | Software Engineer |
| Joel Thompson | Visual Effects Editor |
| Tim Ranck | Animation Supervisor |
| Chris Waegner | Digital Effects Supervisor |
| Patrick Haskew | Pre-Visualization Supervisor |
| Steph Lynn Robinson | Stereoscopic Coordinator |
| Francisco Ramirez | Visual Effects Editor |
| Theodore Bialek | Visual Effects Supervisor |
| Simone Kraus Townsend | Animation Supervisor |
| Carlos-Christian Nickel | CG Supervisor |
| Kevin Culhane | Lead Animator |
| Scott Englert | Software Engineer |
| Kevin Kitchel | Visual Effects Technical Director |
| Eric Kimelton | Visual Effects Producer |
| Aaron Colman-Hayes | 3D Modeller |
| Andrew Zink | CG Supervisor |
| Ellen Hoffmann | Lead Animator |
| Diana Giorgiutti | Visual Effects Producer |
| Nikos Kalaitzidis | Digital Effects Supervisor |
| Kenton Hulme | VFX Editor |
| Jep Hill | Digital Effects Supervisor |
| Brad Alexander | Pre-Visualization Supervisor |
| Xinling Chen | Software Engineer |
| Andy Yamada | Stereoscopic Coordinator |
| Todd Busch | Visual Effects Editor |
| Anik Seguin | Visual Effects Editor |
| Justin Johnson | Digital Effects Supervisor |
| Julius Kwan | Lead Animator |
| Javier Lopez-Duprey | Pre-Visualization Supervisor |
| Lou Pecora | Visual Effects Supervisor |
| Kenneth Au | Visual Effects Supervisor |
| Dan Bethell | Visual Effects Supervisor |
| Brendan Seals | Visual Effects Supervisor |
| Matt Sweat | First Assistant Editor |
| Orlando Hernandez | Gaffer |
| James Morioka | Dialogue Editor |
| Michael Giacchino | Original Music Composer |
| Cameron Steenhagen | Dialogue Editor |
| Vanessa Lapato | Supervising Dialogue Editor |
| Vanessa Lapato | Supervising ADR Editor |
| Avi Arad | Executive Producer |
| Andrea Datzman | Lyricist |
| Dean Bailey | Stunt Driver |
| Jared Losano | Stunt Driver |
| Danny Downey | Stunt Double |
| Evan Dane Taylor | Stunt Double |
| Cody Banta | Stunts |
| Elizabeth Classen | Stunts |
| Scott Dale | Stunt Driver |
| Alrik Kreemke | Stunt Double |
| Christopher 'Critter' Antonucci | Stunts |
| Charles Barden | Stunts |
| Thomas DuPont | Stunts |
| Katie Kramer | Stunt Double |
| Kate Boyer | Stunts |
| Marcelle Coletti | Stunts |
| George Cottle | Stunt Coordinator |
| Hamid-Reza Benjamin Thompson | Stunt Double |
| Ilram Choi | Fight Choreographer |
| Nitasha Bhambree | Stunts |
| Chelsea Bruland | Utility Stunts |
| Stephen Conroy | Stunts |
| Allan Padelford | Stunt Driver |
| Tye Claybrook Jr. | Stunts |
| Shane Daniels | Stunts |
| Kevin Dyer | Stunts |
| Trampas Thompson | Stunt Double |
| Marc Canonizado | Stunts |
| Kevin Cassidy | Stunts |
| Sarah Reagin | Stunts |
| Keith Splinter Davis | Stunts |
| David Elson | Stunt Double |
| Floyd Anthony Johns Jr. | Stunt Double |
| Kelly Bellini | Stunts |
| Dan Brown | Stunts |
| Jwaundace Candece | Stunts |
| Sebastiano Cartier | Stunts |
| Blaise Corrigan | Stunts |
| Elizabeth Davidovich | Stunts |
| Holland Diaz | Stunt Double |
| Niko Dalman | Stunts |
| Joe Dryden | Utility Stunts |
| Richard Marrero | Stunt Driver |
| Gianni Biasetti Jr. | Stunts |
| Jared Burke | Stunts |
| Alvin Chong | Stunts |
| Sean Christopher | Utility Stunts |
| Florian Hotz | Stunt Coordinator |
| Donald K. Overstreet | Stunt Double |
| Adrienne Ballenger | Stunts |
| Chris Cenatiempo | Stunts |
| Brittini London | Stunt Double |
| Amadei Weiland | Stunt Double |
| Davide Binello | Matte Painter |
| Harrison Osterfield | Actor's Assistant |
| Jon Watts | Director |
| Louis D'Esposito | Executive Producer |
| Victoria Alonso | Executive Producer |
| Patricia Whitcher | Executive Producer |
| Jeremy Latcham | Executive Producer |
| Mitchell Bell | Co-Producer |
| Chris Silcox | Stunt Double |
| Rachel O'Connor | Co-Producer |
| Nancy Thurston | Stunts |
| Caroline Vexler | Stunts |
| Jonathan Goldstein | Screenplay |
| John Francis Daley | Screenplay |
| Jon Watts | Screenplay |
| Christopher Ford | Screenplay |
| Chris McKenna | Screenplay |
| Erik Sommers | Screenplay |
| Jay Oliva | Storyboard Artist |
| James Gunn | Second Unit Director |
| Mario Richard | Animation |
| Noon Orsatti | Stunts |
| Kandis Hargrave | Stunts |
| Riley Flanagan | Set Production Assistant |
| Shawnna Thibodeau | Stunts |
| Casey Ann Zeller | Stunts |
| Paul E. Short | Stunts |
| Peter Epstein | Stunts |
| Anthony N. | Stunts |
| Duffy Gaver | Stunts |
| Alice Rietveld | Stunts |
| Stan Lee | Comic Book |
| Steve Ditko | Comic Book |
| Joe Simon | Characters |
| Jack Kirby | Characters |
