 | Ray Romano als Manny (voice) |
 | John Leguizamo als Sid (voice) |
 | Denis Leary als Diego (voice) |
 | Seann William Scott als Crash (voice) |
 | Josh Peck als Eddie (voice) |
 | Queen Latifah als Ellie (voice) |
 | Jennifer Lopez als Shira (voice) |
 | Peter Dinklage als Captain Gutt (voice) |
 | Wanda Sykes als Granny (voice) |
 | Keke Palmer als Peaches (voice) |
 | Josh Gad als Louis (voice) |
 | Nick Frost als Flynn (voice) |
 | Aziz Ansari als Squint (voice) |
 | Alain Chabat als Silas (voice) |
 | Kunal Nayyar als Gupta (voice) |
 | Drake als Ethan (voice) |
 | Nicki Minaj als Steffie (voice) |
 | Rebel Wilson als Raz (voice) |
 | Alan Tudyk als Milton / Hunky Siren (voice) |
 | Ester Dean als Female Siren (voice) |
 | Eddie 'Piolin' Sotelo als Uncle Fungus (voice) |
 | Joy Behar als Eunice (voice) |
 | Heather Morris als Katie (voice) |
 | Chris Wedge als Scrat (voice) |
 | Christopher Campbell als Creature Siren (voice) |
 | Karen Disher als Scratte (voice) |
 | Marieve Herington als Additional Voices (voice) |
| Lucas Leguizamo als Additional Voices (voice) |
| Allegra Leguizamo als Additional Voices (voice) |
| Jason Fricchione als Dumb Mammoth / Various (voice) |
 | Ben Gleib als Marshall (voice) |
| George Jacobs als Beaver (voice) |
| James Palumbo als Panicked Start (voice) |
 | Simon Pegg als Buck (voice) |
| Alexandra Romano als Meghan (voice) |
 | Patrick Stewart als Ariscratle (voice) |
 | Brian Scott McFadden als Additional Voices (voice) |
| Ashley Albert als Additional Voices (voice) |
 | Edita Brychta als Additional Voices (voice) |
 | Dennis T. Carnegie als Additional Voices (voice) |
 | Aimée Castle als Additional Voices (voice) |
 | Jim Conroy als Additional Voices (voice) |
| Jason Harris als Additional Voices (voice) |
 | Sondra James als Additional Voices (voice) |
 | Alexa Kahn als Additional Voices (voice) |
 | Bill Lobley als Additional Voices (voice) |
 | Chris Phillips als Additional Voices (voice) |
 | Tara Sands als Additional Voices (voice) |
 | Keith Silverstein als Additional Voices (voice) |
| Steve Martino | Director |
| Jason Fuchs | Screenplay |
| Michael Berg | Screenplay |
| Chris Wedge | Executive Producer |
| Mike Thurmeier | Director |
| James Palumbo | Editor |
| John Powell | Original Music Composer |
| Cal Brunker | Storyboard |
| Pablo Calvillo | Layout |
| Arun Ram-Mohan | Lighting Artist |
| Tyler Carter | Art Direction |
| Matthew J. Munn | Animation |
| Diego Garzon | Script Supervisor |
| Michael Daley | Story Artist |
| Moroni Taylor | Storyboard Artist |
| Michael Tanzillo | Visual Effects |
| Paul Downs | Animation |
| David Ian Salter | Editor |
| Pedro Eustache | Musician |
| Christian Kaplan | Casting |
| Anthony Nisi | Production Manager |
| Kirk Garfield | CG Supervisor |
| Lori Forte | Producer |
| John C. Donkin | Producer |
| Carlos Saldanha | Executive Producer |
| Michael Berg | Story |
| Lori Forte | Story |
| Anthony Pitone | First Assistant Editor |
| Randy Thom | Sound Re-Recording Mixer |
| Lora Hirschberg | Sound Re-Recording Mixer |
| Randy Thom | Sound Designer |
| Randy Thom | Supervising Sound Editor |
| Michael Silvers | Supervising Sound Editor |
| Brian Chumney | Dialogue Editor |
| Scott R. Lewis | Additional Sound Re-Recording Mixer |
| David Parker | Additional Sound Re-Recording Mixer |
| Jim Passon | Color Timer |
| Amy Pawlowski | Digital Intermediate Editor |
| Eileen Godoy | Digital Intermediate Producer |
| Natasha Leonnet | Digital Intermediate Colorist |
| Thomas A. Carlson | Music Editor |
| Frank Rinella | Foley Mixer |
| Jana Vance | Foley Artist |
| Dennie Thorpe | Foley Artist |
| Andrea Gard | Foley Recordist |
| Clint Smith | Foley Recordist |
| Stephen Urata | Sound Recordist |
| Casey Langfelder | Apprentice Sound Editor |
| Pascal Garneau | Foley Editor |
| Robert Shoup | Foley Editor |
| Scott Guitteau | Sound Effects Editor |
| David Chrastka | Sound Effects Editor |
| Nia Hansen | Sound Effects Editor |
| Teresa Eckton | Sound Effects Editor |
