 | Nathan Fillion als Bill Pardy |
 | Michael Rooker als Grant Grant |
 | Elizabeth Banks als Starla Grant |
 | Gregg Henry als Jack MacReady |
 | Tania Saulnier als Kylie Strutemyer |
 | Don Thompson als Wally |
 | Brenda James als Brenda Gutierrez |
 | Jennifer Copping als Margaret |
 | Jenna Fischer als Shelby |
 | Haig Sutherland als Trevor |
 | William MacDonald als Mr. Strutemyer |
 | Iris Quinn als Mrs. Strutemyer |
 | Matreya Fedor als Emily Strutemyer |
| Amber Lee Bartlett als Jenna Strutemyer |
 | Xantha Radley als Uptight Mom |
 | Dustin Milligan als Drawing Boy |
 | Lloyd Kaufman als Sad Drunk |
 | Zak Ludwig als Gina Kid |
 | Tom Heaton als Tourneur |
 | Mary Black als Woman in Basement |
 | Ben Cotton als Charlie |
 | Lorena Gale als Janene |
 | Dee Jay Jackson als Dwight |
| Nicholas Podbrey als Diseased Grant part 1 |
 | Malcolm Scott als Dude Joining Grant |
 | Darren Shahlavi als Brenda's Husband |
 | Kathryn Kirkpatrick als Karaoke Woman |
| Corb Lund als Lead Singer |
| Michael Cromien als Fitzgibbon |
| Robert Musnicki als Diseased Leader |
 | Stephen Park als Gleeked on Guy |
| Nicholas Podbrey als Diseased Grant #1 |
 | Jeny Cassady als Diseased Grant #2 |
| Alette Falle als Diseased Grant #3 |
| Matt McInnis als Head-Shot Norman |
 | James Gunn als Hank (uncredited) |
 | Magda Apanowicz als Friend (uncredited) |
| Rick Morwick als Truck Driver (uncredited) |
 | Rob Zombie als Dr. Karl (voice) |
 | Mark Torgl als Melvin Junko (Archive footage) |
| Eric Newman | Producer |
| Marc Abraham | Executive Producer |
| John Axelrad | Editor |
| James Gunn | Writer |
| Scott Niemeyer | Executive Producer |
| James Gunn | Director |
| Paul Brooks | Producer |
| Rachel Wyn Dunn | Compositors |
| Patricia Hargreaves | Costume Design |
| Gregory Middleton | Director of Photography |
| Jonathan Shore | Associate Producer |
| Andrew Neskoromny | Production Design |
| Dario DiSanto | Foley Editor |
| Dave Brown | Grip |
| Aynsley Baldwin | Post Production Assistant |
| Danelle Vierkant | Creature Design |
| Roberta L. Asman | Post Production Accountant |
| Carol Hocking | Production Coordinator |
| Kevin Belen | Sound Re-Recording Mixer |
| Jean Tejkel | Foley Mixer |
| David Alexander | 3D Animator |
| Barb Benoit | Compositor |
| Chris Holmes | Compositing Supervisor |
| James Forsyth | Extras Casting |
| Joanna L. Jones | Executive In Charge Of Post Production |
| Robert Foreman | Carpenter |
| Rick Kramer | Greensman |
| Bryan C. Knight | First Assistant Director |
| Stephanie Rossel | Script Supervisor |
| Maureen Murphy | Foley Artist |
| Audrey Price | Visual Effects Production Assistant |
| Allan Walker | Matte Painter |
| Colleen Bolton | Casting Associate |
| Helen Menyes | Standby Painter |
| Kris Casavant | Assistant Sound Editor |
| Ron Buyck | Transportation Captain |
| Ann-Marie Blommaert | Visual Effects Compositor |
| Joshua Kjorven | Camera Trainee |
| Adam de Bosch Kemper | Digital Effects Supervisor |
| Jennifer Powell-Folk | First Assistant Makeup Artist |
| Jeffrey Kleiser | Senior Visual Effects Supervisor |
| Michael Alderking | Location Production Assistant |
| Tyler Bates | Original Music Composer |
| Monica Huppert | Key Makeup Artist |
| Eric Clement | CG Supervisor |
| Frank Turcotte | Layout |
| Susan Steeno | Publicist |
| Megan Harkness | Assistant Makeup Artist |
| Michael Jovanovski | Lead Set Dresser |
| Douglas Aiken | Digital Compositor |
| Jon Campfens | Visual Effects Supervisor |
| Andrew Pedley | Video Assist Operator |
| Tim Williams | Orchestrator |
| Lauren M. Walker | Truck Costumer |
| Mark Noda | Boom Operator |
| Hal Beckett | Music Editor |
| Robin Auckland | Assistant Craft Service |
| Arthur Montreuil | Color Timer |
| Philip Hunter | Dialogue Editor |
| Chris Doss | Executive in Charge of Finance |
| Ling Yang | Storyboard Artist |
| Geraldine Brezca | First Assistant Camera |
| Paul Birch | Additional Grip |
| Mark Brown | Dolly Grip |
| Shane Lennox | Assistant Location Manager |
| Allan Wilson | Conductor |
| Laura Arcangeli | Assistant Chef |
| Kelly Golden | Sculptor |
| Michael Church | Set Dresser |
| John Brake | Systems Administrators & Support |
| Joel Hurley | Location Scout |
| Greg Jackson | Location Manager |
| Kyle Doig | Animal Wrangler |
| Byron Drinkle | Playback Coordinator |
| Jeff Levine | Co-Producer |
| Glen A. Dickson | Additional Camera |
| Ken Dhaliwal | Finance |
| Jeff Baker | Technical Supervisor |
| Scott J. Ateah | Second Unit Director |
| John Johnston | Transportation Coordinator |
| Matthew Talbot-Kelly | Digital Supervisor |
| Matt Kunau | Dolby Consultant |
| Marty McInally | Steadicam Operator |
| Shane Vieau | Set Decoration |
| Michael Sullivan | Lead Painter |
| Judi Stackaruk | Set Decoration Buyer |
| Deni King | ADR Supervisor |
| John Sleep | Special Effects Coordinator |
| Scott J. Ateah | Stunt Coordinator |
| Ken Atherton | Driver |
| Trevor Westerhoff | Production Coordinator |
| Larry Sostad | Security Coordinator |
| Dan Lee West | Producer |
| Michael N. Wong | Art Direction |
| John Marcynuk | Assistant Art Director |
| Patrick Latarius | Construction Coordinator |
| David Dowling | Property Master |
| Tannis Hegan | Makeup Effects |
| Tim Walston | Sound Designer |
| Louise Barkholt | Visual Effects Producer |
| Michael Corrado | Construction Buyer |
| Sergio Lavilla | Set Buyer |
| Stefan Burianyk | Best Boy Grip |
| Drake Conrad | Digital Colorist |
| Deborah Morriss | Paint Coordinator |
| Ian Jones | Sound Assistant |
| Anke Bakker | Sound Supervisor |
| Shawn Williamson | Line Producer |
| Taku Dazai | Animatronics Designer |
| Brad Van Arragon | Unit Production Manager |
| Rick Hannigan | Production Supervisor |
| John Barrigar | 3D Artist |
| Debbie Tallman | Assistant Costume Designer |
| Tony Alcantar | Dialogue Coach |
| Mike Paprocki | Sound Effects Editor |
| Joe Colwell | Prosthetics |
| Emma Pittson | Lead Animator |
| Aisla Webster | Post Production Coordinator |
| Gilbert Jamault | Generator Operator |
| Aaron Dem | Executive Visual Effects Producer |
| Rob Fournier | Armorer |
| Sarah Webster | Music Supervisor |
| Landon Medeiros | Visual Effects Editor |
| Karin Behrenz | Third Assistant Director |
| Jose R. Castellon | ADR Recordist |
| Katie Baker | Accountant |
| Shannon Harron | Payroll Accountant |
| Danna Rutherford | Key Hair Stylist |
| Tavis Gogal | Construction Foreman |
| Gordon Alyward | Transportation Co-Captain |
| Kelly Fry | Craft Service |
| Tom Kolafa | Best Boy Electric |
| Stewart Henshaw | Gaffer |
| Alexis Hinde | Second Assistant Director |
| Wes Hamby | Assistant Property Master |
| Carlos Bolbrugge | Graphic Designer |
| Chris Helcermanas-Benge | Still Photographer |
| Francisco Koch | ADR Mixer |
| John Bozzalla | Visual Effects Production Manager |
| Gary Lam | Assistant Editor |
| Norm Waitt | Executive Producer |
| Doris Deutschmann | Art Department Coordinator |
| Steve Larsen | Rigging Grip |
| Steward Burris | Animation Director |
| Nerses Gezalyan | Sound Mixer |
| Robert Musnicki | Stand In |
| Todd Zeller | Unit Publicist |
| Charron Hume | Costumer |
| Francois Garcia | Head of Production |
| Thomas A. Bliss | Executive Producer |
| Keith A. Parent | Costume Supervisor |
| Tracey Chapman | Rigging Gaffer |
| Jennifer Mylrea | Stunts |
| Ed Anders | Stunts |
| Ryan Ennis | Stunts |
| Brett Armstrong | Stunts |
| Corbin Fox | Stunts |
| Kim Howey | Stunts |
| Mike Dopud | Stunts |
| John Ulmer | Stunts |
| Owen Walstrom | Stunts |
| Shawn Stewart | Stunts |
| Rob Wilton | Stunts |
