 | Dwayne Johnson als Davis Okoye |
 | Naomie Harris als Dr. Kate Caldwell |
 | Malin Åkerman als Claire Wyden |
 | Jeffrey Dean Morgan als Harvey Russell |
 | Jake Lacy als Brett Wyden |
 | Joe Manganiello als Burke |
 | Marley Shelton als Dr. Kerry Atkins |
 | P.J. Byrne als Nelson |
 | Demetrius Grosse als Colonel Blake |
 | Jack Quaid als Connor |
 | Breanne Hill als Amy |
 | Matt Gerald als Zammit |
 | Will Yun Lee als Agent Park |
 | Urijah Faber als Garrick |
 | Bruce Blackshear als Taylor |
 | Jason Liles als George |
 | Mac Wells als Communications Officer |
 | Allyssa Brooke als Radar Officer |
 | Stephen Dunlevy als First MP |
 | Danny Le Boyer als Second MP |
 | Alan Boell als Officer |
 | Adam Sztykiel als C-17 Pilot |
 | DJames Jones als Captain Evans |
 | Gary Weeks als Police Captain |
 | David An als Kaplan |
 | Arnold Chun als Commanding Officer |
 | Gregory Hoyt als Pilot |
 | Suzanne Cotsakos als Co-Pilot |
 | Ross Philips als Soldier with SAT Phone |
 | Bernard Dowdell als Air Force Captain |
| Robin Meade als HLN Reporter |
| Chris Murphy als San Diego Newscaster #1 |
| Maria Arcega-Dunn als San Diego Newscaster #2 |
| Jason Sloss als San Diego Reporter |
| Shannon Halligan als Reporter on the Ground |
| Andy John Roesgen als Local Chicago Reporter |
 | John Crow als Mt. Rushmore Reporter |
 | Lane Carlock als Zoo Reporter |
| Wendy Yang als Willis Tower Reporter |
| Skye Notary als Female Gorilla #1 |
| Willow Notary als Female Gorilla #2 |
 | Chase Anderson als Kid (uncredited) |
 | Jeff Baird als Swat Team (uncredited) |
 | Jasmine Bolton als Zoo Kid (uncredited) |
 | Brandon Bowens als National guard (uncredited) |
 | Pete Burris als Rancher (uncredited) |
 | Andrea Antonio Canal als Lieutenant Colonel (uncredited) |
 | Timothy Carr als Mercenary (uncredited) |
| David Dunston als Agent (uncredited) |
 | Lex Elle als National Guardsman (uncredited) |
 | Matthew Ewald als USAF Pilot / Tobias Denny (uncredited) |
 | Eric Ian als Mercenary (uncredited) |
 | Tyler Jackson als National Guard (uncredited) |
 | Perry Zulu Jr. als National Guard (uncredited) |
 | Jessica Medina als Scuba Diver Girlfriend (uncredited) |
 | Lauren Michele als Civilian (uncredited) |
 | Andrew Morgado als Pilot (uncredited) |
 | David Oelert als National Guardsman (uncredited) |
 | Valentina Latyna Plascencia als Mother (uncredited) |
 | Rekkhan als School Teacher (uncredited) |
 | Henardo Rodriguez als Zoologist (uncredited) |
 | Jamin Thompson als Army Soldier (uncredited) |
 | Joey Thurmond als Calvin Mangum (uncredited) |
 | Giota Trakas als Teacher (uncredited) |
 | Michael David Yuhl als Navy Officer (uncredited) |
| Zion Bly als Evacuating School Kid (uncredited) |
| Camden Haydon als Zoo Kid (uncredited) |
| Brad Peyton | Director |
| Ryan Condal | Screenplay |
| Ryan Engle | Screenplay |
| Carlton Cuse | Screenplay |
| Jaron Presant | Director of Photography |
| Andrew Lockington | Music |
| Jim May | Editor |
| Beau Flynn | Producer |
| Hiram Garcia | Producer |
| Brad Peyton | Producer |
| John Rickard | Producer |
| Bob Ducsay | Editor |
| Laurel Bergman | Art Direction |
| Elliott Glick | Art Direction |
| Drew Monahan | Art Direction |
| Mark Walters | Art Direction |
| Barry Chusid | Production Design |
| Tom Reta | Supervising Art Director |
| Melissa Bruning | Costume Design |
| Adruitha Lee | Hair Department Head |
| Leay Cangelosi | Hairstylist |
| Jennifer Hodges | Hairstylist |
| Lindsay McAllister | Hairstylist |
| Tim Toth | Hairstylist |
| Mary Everett | Key Hair Stylist |
| Leslie D. Bennett | Key Hair Stylist |
| Tarra D. Day | Makeup Department Head |
| Sarah Mays | Makeup Department Head |
| Erin Keith | Key Makeup Artist |
| Stephanie Arble | Makeup Artist |
| Geno Freeman | Makeup Artist |
| Gaby Macias | Makeup Artist |
| Jorie Malan | Makeup Artist |
| Seidah Nichols | Makeup Artist |
| Leo Satkovich | Makeup Artist |
| Ron Licari | Armorer |
| Heather Elwell | Art Department Coordinator |
| Shawn D. Bronson | Assistant Art Director |
| Sandra Doyle Carmola | Assistant Art Director |
| Anne Costa | Assistant Art Director |
| Kristen Nowotarski | Assistant Art Director |
| Jared Krichevsky | Creature Design |
| Jonas Kirk | Construction Coordinator |
| Mychael Bates | Property Master |
| Michael Panevics | Property Master |
| Michael Panevics | Armorer |
| Colin Bach | Property Master |
| Cierra Madison | Set Designer |
| Sam Page | Set Designer |
| Anshuman Prasad | Set Designer |
| Mike Stassi | Set Designer |
| Randall D. Wilkins | Set Designer |
| Mark Keever | Set Dresser |
| David Ladish | Set Dresser |
| Maxfield Ladish | Set Dresser |
| Peter Gulla | Additional Photography |
| Ross Sebek | Additional Camera |
| Eric Dvorsky | Aerial Camera Technician |
| Dylan Goss | Aerial Director of Photography |
| BJ McDonnell | Additional Photography |
| Thomas Lappin | Camera Operator |
| Danny Eckler | Camera Operator |
| Troy N. Wade | Dolly Grip |
| Robert McFall | Dolly Grip |
| Jeremy Wren | Dolly Grip |
| Raul Flores | Electrician |
| Jonathan McKeown | Electrician |
| Malachi Roberts | Electrician |
| Oscar Valdivia | Electrician |
| Rafael E. Sánchez | Gaffer |
| Jaim O'Neil | Gaffer |
| Ed Maloney | Gaffer |
| Michael Duarte | Key Grip |
| Darwin Montana Browne | Key Grip |
| Thomas Browne | Rigging Grip |
| Jason M. Thompson | Lighting Technician |
| Bill Chapman | Rigging Grip |
| Geoff Ernst | Lighting Technician |
| Ryan Perdew | Lighting Technician |
| David McLendon | Lighting Technician |
| Mikey Gipson | Lighting Technician |
| Mark Goellnicht | Steadicam Operator |
| Frank Masi | Still Photographer |
| Jason Talbert | Techno Crane Operator |
| Robert A. Sutton | Techno Crane Operator |
| Adam Meadows | Video Assist Operator |
| Tara Feldstein Bennett | Casting |
| Chase Paris | Casting |
| Benj Gibicsar | Ager/Dyer |
| Layne Brightwell | Costume Supervisor |
| Ellen Semones | Key Costumer |
| Sara Pope | Seamstress |
| English Benning | Set Costumer |
| Kaylie Hamborg | Set Costumer |
| Tony Kochinas | Set Costumer |
| Margaret Palmer | Set Costumer |
| Walter Volpatto | Digital Intermediate |
| Sam Bollinger | First Assistant Editor |
| Esther Sokolow | Assistant Editor |
| Larry Zanoff | Armorer |
| Frédéric North | Aerial Coordinator |
| Frédéric North | Pilot |
| Doug Uttecht | Pilot |
| Shane B. Scott | Script Supervisor |
| Robin Meyers | Script Supervisor |
| Mary Tallman | Script Supervisor |
| Janine Gosselin | Script Supervisor |
| Christopher M. Searcey | Script Supervisor |
| Brian Runnels | 3D Coordinator |
| David Clayton | Animation Supervisor |
| Eric Petey | Animation Supervisor |
| Daniele Tosti | CG Supervisor |
| Ben Kilgore | Creature Technical Director |
| Jerry Kung | Lead Animator |
| James Meikle | VFX Editor |
| Bryce Gardiner | VFX Editor |
| Nick Bernardi | Visual Effects Coordinator |
| Eric Jacobo | Visual Effects Coordinator |
| Juliette Lemaire | Visual Effects Coordinator |
| Greg Strause | Visual Effects Designer |
| Andrew Ryan Turner | Visual Effects Editor |
| Lei Zhang | Visual Effects Editor |
| Paul V. Molles | Visual Effects Producer |
| Robert Schajer | Visual Effects Producer |
| Paul Kolsanoff | Visual Effects Producer |
| Thrain Shadbolt | Visual Effects Supervisor |
| Colin Strause | Visual Effects Supervisor |
| Erik Winquist | Visual Effects Supervisor |
| Jessica Harris | Visual Effects Supervisor |
| Mike F. Hedayati | Visual Effects Supervisor |
| Rahul Deshprabhu | Visual Effects Technical Director |
| Nicholas Illingworth | Visual Effects Technical Director |
| Zichuan Zhao | Visual Effects Technical Director |
| Niña Laureles | Visual Effects Technical Director |
| Mark Cameron Williams | Visual Effects Technical Director |
| Eric Cook | Special Effects Coordinator |
| Adam Heinis | Special Effects Coordinator |
| J.D. Schwalm | Special Effects Supervisor |
| Travis Misarti | Editorial Production Assistant |
| Adam Sztykiel | Screenplay |
| Ryan Engle | Story |
| Dany Garcia | Executive Producer |
| Ronan Binding | Animation |
| Richard Brener | Executive Producer |
| Michael Disco | Executive Producer |
| Toby Emmerich | Executive Producer |
| Jeffrey Fierson | Executive Producer |
| Wendy Jacobson | Co-Producer |
| Dwayne Johnson | Executive Producer |
| Josh Mack | Co-Producer |
| Darin Read | Associate Producer |
| Dana Robin | Co-Producer |
| Ozzie Scott | Associate Producer |
| Marcus Viscidi | Executive Producer |
| Allison Furgal | Production Supervisor |
| Teodora Ilie | Assistant Production Manager |
| James R. McAllister | Unit Production Manager |
| Darin Read | Post Production Supervisor |
| Dana Robin | Unit Production Manager |
| Anne Taunga | Department Administrator |
| Philip Banks | Second Second Assistant Director |
| Rob Burgess | First Assistant Director |
| Pablo Gambetta | Additional Second Assistant Director |
| Bennett Gammon | Additional Second Assistant Director |
| Richard Goodwin | First Assistant Director |
| Austin Harpole | Second Second Assistant Director |
| Paul Jennings | Second Unit Director |
| Marlee Kamis | Additional Second Assistant Director |
| Rachel Keenan | Production Assistant |
| Dawn Massaro | Second Assistant Director |
| Ryan J. Pezdirc | Additional Second Assistant Director |
| Denise Anderson Poore | Second Assistant Director |
| Robert Ratner | Additional Second Assistant Director |
| Michelle Schrauwers | Second Second Assistant Director |
| Anneke Scott | Second Second Assistant Director |
| Drew Stern Tuya | Second Unit Director |
| Cody Williams | Second Assistant Director |
| Dea Cantu | Script Supervisor |
| Jordan M. Sloane | Script Coordinator |
| Haaron Hines | Stunts |
| Brooke Lyndon-Stanford | Visual Effects Supervisor |
| Satoshi Takazawa | VFX Artist |
| Chang Jung-min | VFX Artist |
| Kelli Victoria Scarangello | Stunts |
| Linda Perlin | Stunts |
| Leiki Veskimets | Production Manager |
| Mallory Thompson | Stunts |
| Gui DaSilva-Greene | Stunts |
| Kandis Hargrave | Stunts |
| Christopher Kelly | Visual Effects |
| Scott Christopher Kelly | Stand In |
| Shauna Galligan | Stunts |
| Natalie M. Meyer | Stunts |
| Tanoai Reed | Stunt Double |
| Hannah Betts | Stunts |
| Anthony N. | Stunts |
| Amy Lynn Tuttle | Stunts |
